TAMALIN and GRM2

Number of citations of the paper that reports this interaction (PubMedID 11850456)
59

Data Source:
HPRD (two hybrid)

		TAMALIN	GRM2
Description		trafficking regulator and scaffold protein tamalin	glutamate metabotropic receptor 2
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse
	Molecular Function	PDZ Domain Binding Small GTPase Binding Identical Protein Binding	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug
Pathways			G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			LY2140023
Diseases
GWAS
Interacting Genes		13 interacting genes: ACE2 CYTH3 DLG4 DOCK1 FYN GABBR2 GRM1 GRM2 GRM3 GRM5 KRT72 RPS6KA1 SRC	31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1
Entrez ID		160622	2912
HPRD ID		17077	04977
Ensembl ID		ENSG00000161835	ENSG00000164082
Uniprot IDs		Q7Z6J2	H7BXL3 Q14416
PDB IDs		2PNT	4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD
Enriched GO Terms of Interacting Partners?		Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Activity Chemical Synaptic Transmission Scaffold Protein Binding Trans-synaptic Signaling Synaptic Signaling Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Negative Regulation Of Adenylate Cyclase Activity Glutamatergic Synapse Cell-cell Signaling Neuron Projection Astrocyte Projection Signaling Cell Communication Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Group II Metabotropic Glutamate Receptor Activity Modulation Of Chemical Synaptic Transmission G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled Receptor Activity Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Dendrite Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Phospholipase Activator Activity Postsynaptic Density Schaffer Collateral - CA1 Synapse Regulation Of Signal Transduction Postsynaptic Density Membrane Protein Tyrosine Kinase Activator Activity Amino Acid Transport Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Dendritic Spine	Membrane Plasma Membrane
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