GRM2 and CCDC107

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRM2	CCDC107
Description		glutamate metabotropic receptor 2	coiled-coil domain containing 107
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse	Membrane
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		LY2140023
Diseases
GWAS			Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	9 interacting genes: ADGRE2 ADIPOQ APP GRM2 KPNA2 SLC35B1 TNF UBQLN4 UNC93B1
Entrez ID		2912	203260
HPRD ID		04977	14545
Ensembl ID		ENSG00000164082	ENSG00000159884
Uniprot IDs		H7BXL3 Q14416	Q8WV48
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane	Positive Regulation Of Cytokine Production Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Astrocyte Projection Regulation Of Cytokine Production Positive Regulation Of Membrane Protein Ectodomain Proteolysis Endoplasmic Reticulum Positive Regulation Of CAMP/PKA Signal Transduction Toll-like Receptor 3 Signaling Pathway Astrocyte Activation Negative Regulation Of Blood Circulation Modulation Of Chemical Synaptic Transmission Regulation Of Interleukin-6 Production Regulation Of Amyloid-beta Clearance Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of DNA Metabolic Process Endolysosomal Toll-like Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Secretion By Cell Non-canonical NF-kappaB Signal Transduction Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Gene Expression Response To Stress Negative Regulation Of Synaptic Transmission Regulation Of Secretion Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of CAMP/PKA Signal Transduction Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Macrophage Activation Regulation Of ERK1 And ERK2 Cascade Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Localization
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