GRM2 and GNAQ

Number of citations of the paper that reports this interaction (PubMedID 8863838)
0

Data Source:
HPRD (in vivo)

		GRM2	GNAQ
Description		glutamate metabotropic receptor 2	G protein subunit alpha q
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Membrane Nuclear Membrane Extracellular Exosome Postsynaptic Cytosol
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity GTPase Activator Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuropeptide Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Hormone-mediated Signaling Pathway Regulation Of Platelet Activation Response To Prostaglandin E Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Acidic PH Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		LY2140023
Diseases
GWAS			Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NHERF1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		2912	2776
HPRD ID		04977	02998
Ensembl ID		ENSG00000164082	ENSG00000156052
Uniprot IDs		H7BXL3 Q14416	A0A024R240 P50148
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD	6VU5 7EZM 7F6G 7F6H 7F6I 7F8W 7W3Z 7W40 7XOW 8G59 8IA7 8IYS 8J9N 8JPB 8JPC 8JPE 8SZG 8UQN 8UQO 8XGO 8XGS 8Y52 8ZJD 8ZJE 9K27
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Regulation Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality System Process Serotonin Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Membrane G Protein-coupled Serotonin Receptor Activity Cell-cell Signaling Regulation Of Amine Transport Regulation Of Sequestering Of Calcium Ion G Protein-coupled Serotonin Receptor Complex Signaling Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity Cell Communication Calcium Ion Transmembrane Import Into Cytosol Regulation Of System Process G Protein-coupled Serotonin Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Muscle System Process GTPase Activator Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Secretion Phospholipase C-activating Serotonin Receptor Signaling Pathway Muscle Contraction Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Serotonin Binding Guanyl-nucleotide Exchange Factor Activity Regulation Of Secretion By Cell
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