GRM2 and TFRC

Number of citations of the paper that reports this interaction (PubMedID 36779763)
62

Data Source:
BioGRID (pull down)

		GRM2	TFRC
Description		glutamate metabotropic receptor 2	transferrin receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse	Extracellular Region Extracellular Space Endosome Early Endosome Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Melanosome Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Blood Microparticle Postsynapse Postsynaptic Recycling Endosome Membrane Glutamatergic Synapse Extracellular Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Protein Kinase Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein-folding Chaperone Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug	Regulation Of Cell Growth Response To Hypoxia Iron Ion Transport Intracellular Iron Ion Homeostasis Endocytosis Receptor-mediated Endocytosis Acute-phase Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Nutrient Response To Iron Ion Response To Manganese Ion Positive Regulation Of Gene Expression Negative Regulation Of Mitochondrial Fusion Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Response To Retinoic Acid Transferrin Transport Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Isotype Switching Response To Copper Ion Symbiont Entry Into Host Cell Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Xenobiotic Stimulus Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Transport Across Blood-brain Barrier Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle Transferrin endocytosis and recycling RND2 GTPase cycle RND1 GTPase cycle Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		LY2140023	Iron Ferrous sulfate anhydrous Ferric cation Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Tetraferric tricitrate decahydrate Ferric derisomaltose
Diseases
GWAS			Asthma ( 31959851 30929738) Asthma (adult onset) ( 30929738) Heel bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340 33536631) Mean corpuscular hemoglobin ( 19862010 20139978 32888494 28453575 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 19862010 20139978 28453575 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 32499647)
Interacting Genes		31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	35 interacting genes: ACAP1 AQP6 ARL13B ASGR2 B4GALT1 C1orf159 CD247 CD4 CREB3L1 FAM209A FAM210B GABARAP GET1 GPR152 GRM2 HFE HIBADH LHFPL5 LMNA MFF MGST3 PAGE1 PINX1 RAB5B RAB8A RANBP9 RASSF3 RELL2 RMDN3 SGTA SLC10A1 SLC18A1 SNCA TF TINF2
Entrez ID		2912	7037
HPRD ID		04977	01812
Ensembl ID		ENSG00000164082	ENSG00000072274
Uniprot IDs		H7BXL3 Q14416	A0A8V8TM46 A8K6Q8 B7Z2I6 G3V0E5 P02786
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I 6OKD 6W3H 6WRV 6WRW 6WRX 6Y76 7ZQS 8P0Z
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane	Membrane Protein Tyrosine Kinase Binding Beta-tubulin Binding Response To Iron Ion Mitochondrial Outer Membrane HFE-transferrin Receptor Complex Cellular Response To Iron Ion Transferrin Receptor Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Catecholamine Uptake Dopamine Uptake Protein Localization To Chromosome, Telomeric Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Basal Part Of Cell Tail-anchored Membrane Protein Insertion Into ER Membrane T Cell Receptor Complex Regulation Of Glutamate Secretion Establishment Of Protein Localization Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Protein Targeting Neurotransmitter Reuptake Dopamine Transport Ferrous Iron Binding Negative Regulation Of Telomere Maintenance Via Telomerase Cytoplasmic Vesicle Nitrate Transmembrane Transporter Activity Plasma Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Positive Regulation Of Circulating Fibrinogen Levels Secretory Granule Membrane Regulation Of Dopamine Secretion Multicellular Organismal-level Iron Ion Homeostasis Negative Regulation Of Protein Catabolic Process Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Telomere Maintenance Non-motile Cilium Regulation Of Long-term Neuronal Synaptic Plasticity Protein Insertion Into ER Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Targeting To ER Positive Regulation Of Proteasomal Protein Catabolic Process Monoamine Transport Neurotransmitter Uptake Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity
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