TAMALIN and GABBR2

Number of citations of the paper that reports this interaction (PubMedID 11850456)
59

Data Source:
HPRD (two hybrid)

		TAMALIN	GABBR2
Description		trafficking regulator and scaffold protein tamalin	gamma-aminobutyric acid type B receptor subunit 2
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Cytoplasm Plasma Membrane Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Synapse Postsynaptic Membrane GABA Receptor Complex G Protein-coupled GABA Receptor Complex
	Molecular Function	PDZ Domain Binding Small GTPase Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding GABA Receptor Activity Protein Heterodimerization Activity
	Biological Process	Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, GABAergic Neuron-glial Cell Signaling
Pathways			Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil Sodium oxybate
Diseases
GWAS			Autism spectrum disorder ( 34069769) Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectory ( 27980656) tricyclic pyrone compound response (IC50) ( 33610756)
Interacting Genes		13 interacting genes: ACE2 CYTH3 DLG4 DOCK1 FYN GABBR2 GRM1 GRM2 GRM3 GRM5 KRT72 RPS6KA1 SRC	15 interacting genes: ATF4 ATF5 DRD2 GABBR1 GADD45G GLP1R HTR1A KCTD12 NSF RFXAP SAP30 SH3GL3 SPIN1 SPTLC1 TAMALIN
Entrez ID		160622	9568
HPRD ID		17077	09552
Ensembl ID		ENSG00000161835	ENSG00000136928
Uniprot IDs		Q7Z6J2	H9NIL8 O75899
PDB IDs		2PNT	4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S 7CA3 7CA5 7CUM 7EB2
Enriched GO Terms of Interacting Partners?		Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Activity Chemical Synaptic Transmission Scaffold Protein Binding Trans-synaptic Signaling Synaptic Signaling Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Negative Regulation Of Adenylate Cyclase Activity Glutamatergic Synapse Cell-cell Signaling Neuron Projection Astrocyte Projection Signaling Cell Communication Regulation Of Synaptic Transmission, Glutamatergic G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Group II Metabotropic Glutamate Receptor Activity Modulation Of Chemical Synaptic Transmission G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled Receptor Activity Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Dendrite Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Phospholipase Activator Activity Postsynaptic Density Schaffer Collateral - CA1 Synapse Regulation Of Signal Transduction Postsynaptic Density Membrane Protein Tyrosine Kinase Activator Activity Amino Acid Transport Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Dendritic Spine	Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of Dopamine Secretion Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catecholamine Secretion GABA-ergic Synapse Regulation Of Transport Circadian Rhythm RNA Polymerase II Transcription Regulator Complex Presynaptic Membrane Regulation Of Receptor-mediated Endocytosis Regulation Of Dopamine Secretion G Protein-coupled Receptor Activity Ionotropic Glutamate Receptor Binding Negative Regulation Of Transport Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Dendritic Shaft Response To Nicotine Regulation Of Signaling Negative Regulation Of Blood Pressure Synapse Glucagon-like Peptide 1 Receptor Activity Regulation Of Hormone Levels Circadian Regulation Of Gene Expression Cell-cell Signaling ATF1-ATF4 Transcription Factor Complex Rhythmic Process CHOP-ATF4 Complex Regulation Of Hormone Secretion Regulation Of Blood Circulation G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Vesicle-mediated Transport Regulation Of Secretion Glutamatergic Synapse Regulation Of Secretion By Cell G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Gamma-aminobutyric Acid Secretion Sphinganine Biosynthetic Process Regulation Of Fat Cell Apoptotic Process Sphinganine Metabolic Process
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