GRM2 and ACBD5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRM2	ACBD5
Description		glutamate metabotropic receptor 2	acyl-CoA binding domain containing 5
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse	Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Fatty-acyl-CoA Binding Protein Binding Lipid Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug	Pexophagy Fatty Acid Metabolic Process Autophagy Fatty Acid Catabolic Process
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Peroxisomal lipid metabolism RHOA GTPase cycle RHOC GTPase cycle Class I peroxisomal membrane protein import
Drugs		LY2140023
Diseases
GWAS
Interacting Genes		31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	5 interacting genes: GPR158 GRM2 SLC38A7 STX1B TMEM229B
Entrez ID		2912	91452
HPRD ID		04977	12415
Ensembl ID		ENSG00000164082	ENSG00000107897
Uniprot IDs		H7BXL3 Q14416	A0A7I2V2M2 A0A7I2V347 A0A7I2V556 A0A7I2V690 A0A7I2YQE9 B7Z2A7 B7Z2R7 B7Z9D0 Q5T8D3
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD	3FLV
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane	Positive Regulation Of Neurotransmitter Secretion Axon Modulation Of Chemical Synaptic Transmission L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Regulation Of Neurotransmitter Secretion G Protein-coupled Glycine Receptor Activity Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling Regulation Of Secretion By Cell Regulation Of Secretion Amino Acid Transport Group II Metabotropic Glutamate Receptor Activity Presynaptic Membrane Positive Regulation Of Synaptic Transmission Asparagine Transport L-asparagine Transmembrane Transporter Activity Regulation Of Synaptic Activity Negative Regulation Of Pinocytosis Intracellular Glutamate Homeostasis Postsynaptic Membrane Regulation Of Spontaneous Synaptic Transmission Spontaneous Neurotransmitter Secretion Regulation Of Response To Drug Carboxylic Acid Transport Organic Acid Transport Glutamine Transport L-glutamine Transmembrane Transporter Activity Behavioral Response To Nicotine Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Intracellular Amino Acid Homeostasis Calcium Ion-regulated Exocytosis Of Neurotransmitter Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cell Projection Positive Regulation Of Secretion Synaptic Vesicle Docking Regulation Of Synaptic Vesicle Priming Vesicle Fusion To Plasma Membrane Glutamate Receptor Activity Astrocyte Projection Nuclear Lamina Organic Anion Transport Glutamate Secretion Synaptic Vesicle Membrane Organization G Protein-coupled Receptor Activity Long-term Synaptic Depression G Protein-coupled Glutamate Receptor Signaling Pathway
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