VPS26C and TET2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		VPS26C	TET2
Description		VPS26 endosomal protein sorting factor C	tet methylcytosine dioxygenase 2
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GO Annotations	Cellular Component	Nucleus Endosome	Nucleus Nucleoplasm Chromosome
	Molecular Function	Protein Binding	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Metal Ion Binding Dioxygenase Activity DNA 5-methylcytosine Dioxygenase Activity
	Biological Process	Intracellular Protein Transport Endocytic Recycling	Leukocyte Differentiation Chromatin Organization Protein O-linked Glycosylation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Differentiation Epigenetic Regulation Of Gene Expression Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways			TET1,2,3 and TDG demethylate DNA Specification of primordial germ cells
Drugs
Diseases
GWAS			A body shape index ( 34021172) Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Chronic obstructive pulmonary disease ( 33909500 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) Fasting insulin ( 34059833) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte count ( 29403010 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 24076602 31604244) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of white cells ( 32888494 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Platelet count ( 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Response to esketamine in treatment resistant depression ( 32724131) Self-reported risk-taking behaviour ( 30271922) Serum alkaline phosphatase levels ( 33547301) Tonsillectomy ( 27182965 28928442) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Western dietary pattern ( 28644415)
Interacting Genes		56 interacting genes: AGTPBP1 ARHGAP21 ARHGEF12 ASH1L CA14 CBLB CCDC85A CD55 CIPC DCLK1 DDIT4L DECR2 DNAJB2 DOP1B DSCR4 DSCR8 EPHB6 IFNL1 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MSTO1 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PIGP PMS2 POU3F4 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 RIGI SETMAR SYNJ1 TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655	20 interacting genes: DCAF1 ECD EIF2B2 HLF HOXB9 KEAP1 MED1 MNAT1 OGT PHC1 PKNOX1 RAI1 SMAD1 STAT5A TBC1D4 TFEC VPS26C VPS72 ZCCHC14 ZNF207
Entrez ID		10311	54790
HPRD ID		10390	07876
Ensembl ID		ENSG00000157538	ENSG00000168769
Uniprot IDs		A8MTY9 A8MY26 O14972	A0A158SIU0 Q6N021
PDB IDs		8P0X 8SYN 8SYO 9AU7	4NM6 5D9Y 5DEU 7NE3 7NE6
Enriched GO Terms of Interacting Partners?			Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Macromolecule Biosynthetic Process Chromatin Rhythmic Process Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Response To Peptide Hormone Histone Acetyltransferase Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Mononuclear Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Response To Hormone RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Epithelial Cell Differentiation DNA-binding Transcription Factor Activity Mammary Gland Development Leukocyte Differentiation Nuclear Estrogen Receptor Binding Developmental Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Cell Cycle Hemopoiesis Lactation
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