TET2

Description		tet methylcytosine dioxygenase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome
	Molecular Function	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Metal Ion Binding Dioxygenase Activity DNA 5-methylcytosine Dioxygenase Activity
	Biological Process	Leukocyte Differentiation Chromatin Organization Protein O-linked Glycosylation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Differentiation Epigenetic Regulation Of Gene Expression Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		TET1,2,3 and TDG demethylate DNA Specification of primordial germ cells
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Chronic obstructive pulmonary disease ( 33909500 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) Fasting insulin ( 34059833) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte count ( 29403010 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 24076602 31604244) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of white cells ( 32888494 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Platelet count ( 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Response to esketamine in treatment resistant depression ( 32724131) Self-reported risk-taking behaviour ( 30271922) Serum alkaline phosphatase levels ( 33547301) Tonsillectomy ( 27182965 28928442) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Western dietary pattern ( 28644415)
Novel Interacting Genes		20 novel interacting genes: DCAF1 ECD EIF2B2 HLF HOXB9 KEAP1 MED1 MNAT1 OGT PHC1 PKNOX1 RAI1 SMAD1 STAT5A TBC1D4 TFEC VPS26C VPS72 ZCCHC14 ZNF207
Interacting Genes		20 interacting genes: DCAF1 ECD EIF2B2 HLF HOXB9 KEAP1 MED1 MNAT1 OGT PHC1 PKNOX1 RAI1 SMAD1 STAT5A TBC1D4 TFEC VPS26C VPS72 ZCCHC14 ZNF207
Entrez ID		54790
HPRD ID		07876
Ensembl ID		ENSG00000168769
Uniprot IDs		A0A158SIU0 Q6N021
PDB IDs		4NM6 5D9Y 5DEU 7NE3 7NE6
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Macromolecule Biosynthetic Process Chromatin Rhythmic Process Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Response To Peptide Hormone Histone Acetyltransferase Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Mononuclear Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Response To Hormone RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Epithelial Cell Differentiation DNA-binding Transcription Factor Activity Mammary Gland Development Leukocyte Differentiation Nuclear Estrogen Receptor Binding Developmental Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Cell Cycle Hemopoiesis Lactation
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