VPS26C and U2AF1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		VPS26C	U2AF1
Description		VPS26 endosomal protein sorting factor C	U2 small nuclear RNA auxiliary factor 1
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GO Annotations	Cellular Component	Nucleus Endosome	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome U2AF Complex
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding RS Domain Binding
	Biological Process	Intracellular Protein Transport Endocytic Recycling	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS			Blood and toenail selenium levels ( 25343990)
Interacting Genes		56 interacting genes: AGTPBP1 ARHGAP21 ARHGEF12 ASH1L CA14 CBLB CCDC85A CD55 CIPC DCLK1 DDIT4L DECR2 DNAJB2 DOP1B DSCR4 DSCR8 EPHB6 IFNL1 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MSTO1 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PIGP PMS2 POU3F4 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 RIGI SETMAR SYNJ1 TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655	59 interacting genes: ALG13 AP1B1 AP2B1 CARNMT1 CHERP CIRSR CLK2 CPEB2 DHX38 EFHC2 EPB41 FILNC1 FRA10AC1 HINFP HMGB2 HNRNPK HNRNPM IL7R JMJD6 KRT1 KRT75 MAP1B MEOX2 MFAP1 MLH1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A PTEN RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRNP35 SNRPD1 SRPK1 SRPK2 SRRM4 SRSF1 SRSF2 SRSF3 SUV39H1 TOE1 TRA2B TRAPPC10 U2AF2 VEGFA VPS26C WEE2-AS1 ZCCHC10 ZNF417 ZRANB2 ZRSR2
Entrez ID		10311	7307
HPRD ID		10390	01871
Ensembl ID		ENSG00000157538	ENSG00000160201
Uniprot IDs		A8MTY9 A8MY26 O14972	Q01081 Q7Z780
PDB IDs		8P0X 8SYN 8SYO 9AU7	1JMT
Enriched GO Terms of Interacting Partners?			RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Nucleic Acid Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Splicing Nuclear Speck Nucleic Acid Binding Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Nucleus Nucleoplasm Protein-RNA Complex Assembly Macromolecule Metabolic Process MRNA Binding U2-type Precatalytic Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process U12-type Spliceosomal Complex Negative Regulation Of RNA Splicing U2-type Spliceosomal Complex Positive Regulation Of RNA Splicing Precatalytic Spliceosome U1 SnRNP Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex Negative Regulation Of RNA Metabolic Process Protein-containing Complex Assembly U2-type Prespliceosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process U2 SnRNP Commitment Complex Positive Regulation Of Viral Genome Replication Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA Splice Site Recognition Regulation Of RNA Metabolic Process Protein-containing Complex Organization MRNA 5'-splice Site Recognition T Cell Differentiation In Thymus
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