VPS26C and TAF1C

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		VPS26C	TAF1C
Description		VPS26 endosomal protein sorting factor C	TATA-box binding protein associated factor, RNA polymerase I subunit C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome	Fibrillar Center Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus
	Molecular Function	Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Protein Binding
	Biological Process	Intracellular Protein Transport Endocytic Recycling	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II
Pathways			SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS			Autism ( 22843504) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		56 interacting genes: AGTPBP1 ARHGAP21 ARHGEF12 ASH1L CA14 CBLB CCDC85A CD55 CIPC DCLK1 DDIT4L DECR2 DNAJB2 DOP1B DSCR4 DSCR8 EPHB6 IFNL1 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MSTO1 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PIGP PMS2 POU3F4 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 RIGI SETMAR SYNJ1 TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655	14 interacting genes: H2AX POLR1E RRN3 SMN1 TAF1A TAF1B TBP TK1 TP53 TRIM24 TTR UBTF UFD1 VPS26C
Entrez ID		10311	9013
HPRD ID		10390	05364
Ensembl ID		ENSG00000157538	ENSG00000103168
Uniprot IDs		A8MTY9 A8MY26 O14972	B3KUE8 Q15572
PDB IDs		8P0X 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?			RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase I Transcription Preinitiation Complex Assembly Protein-DNA Complex Assembly RNA Polymerase Transcription Factor SL1 Complex Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Protein-containing Complex Assembly RNA Metabolic Process Protein-containing Complex Organization DNA-templated Transcription Initiation RRNA Transcription RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I RNA Polymerase I General Transcription Initiation Factor Activity Male Germ Cell Nucleus Macromolecule Metabolic Process Nucleoplasm Cellular Component Assembly Nucleus Regulation Of DNA-templated Transcription Initiation Nucleolus DNA Binding Core Promoter Sequence-specific DNA Binding Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Fibroblast Proliferation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Histone H3K23ac Reader Activity RNA Polymerase I Core Factor Complex RNA Polymerase I General Transcription Initiation Factor Binding RRNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Euchromatin MRNA Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Thymidine Kinase Activity Oligodendrocyte Apoptotic Process P53 Binding Negative Regulation Of Pentose-phosphate Shunt
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