VPS26C and ASH1L

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		VPS26C	ASH1L
Description		VPS26 endosomal protein sorting factor C	ASH1 like histone lysine methyltransferase
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GO Annotations	Cellular Component	Nucleus Endosome	Nucleus Nucleoplasm Chromosome Golgi Apparatus Bicellular Tight Junction Anchoring Junction
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Monomethyltransferase Activity Histone H3K36 Trimethyltransferase Activity
	Biological Process	Intracellular Protein Transport Endocytic Recycling	MAPK Cascade Skeletal System Development Negative Regulation Of Acute Inflammatory Response Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Inflammatory Response Single Fertilization Post-embryonic Development Regulation Of Gene Expression Flagellated Sperm Motility Methylation Negative Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Decidualization Sebaceous Gland Development Negative Regulation Of Inflammatory Response Uterus Morphogenesis Tarsal Gland Development Uterine Gland Development
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Dementia with Lewy bodies ( 31065058) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908) Nickel levels ( 26025379) Non-cardia gastric cancer ( 26701879) Parkinson's disease ( 34064523) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		56 interacting genes: AGTPBP1 ARHGAP21 ARHGEF12 ASH1L CA14 CBLB CCDC85A CD55 CIPC DCLK1 DDIT4L DECR2 DNAJB2 DOP1B DSCR4 DSCR8 EPHB6 IFNL1 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MSTO1 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PIGP PMS2 POU3F4 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 RIGI SETMAR SYNJ1 TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655	7 interacting genes: APP DSCR9 H3C1 OXTR RNF10 SMAD7 VPS26C
Entrez ID		10311	55870
HPRD ID		10390	06416
Ensembl ID		ENSG00000157538	ENSG00000116539
Uniprot IDs		A8MTY9 A8MY26 O14972	A0A7I2V316 A0A7I2V3D6 A0A7I2YQU9 Q9NR48
PDB IDs		8P0X 8SYN 8SYO 9AU7	3MQM 3OPE 4YNM 4YNP 4YPA 4YPE 4YPU 6AGO 6INE 6WZW 6X0P 7Y0I
Enriched GO Terms of Interacting Partners?			Regulation Of System Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Blood Circulation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Oxytocin Receptor Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Chondrocyte Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Chondrocyte Proliferation Maternal Process Involved In Parturition Regulation Of Systemic Arterial Blood Pressure By Vasopressin Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Cell Population Proliferation Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Activin Receptor Binding Regulation Of Chondrocyte Development Positive Regulation Of Proteolysis Axon Choice Point Recognition Protein-containing Complex
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