HAGHL and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		HAGHL	C5AR2
Description		hydroxyacylglutathione hydrolase like	complement C5a receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Protein Binding Hydrolase Activity Metal Ion Binding	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process		Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis
Pathways			Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		First fracture in long-term childhood cancer survivors (time to event) ( 33338273) Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		2 interacting genes: C5AR2 TRAF7	17 interacting genes: ABCA7 ACO2 C3 C4A C4orf3 C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		84264	27202
HPRD ID		17087	17072
Ensembl ID		ENSG00000103253	ENSG00000134830
Uniprot IDs		B4DED4 Q6PII5	Q9P296
PDB IDs
Enriched GO Terms of Interacting Partners?
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