TCEA3 and LEO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TCEA3	LEO1
Description		transcription elongation factor A3	LEO1 homolog, Paf1/RNA polymerase II complex component
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Endodermal Cell Fate Commitment Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation
Pathways			Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Creatinine levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) HDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) QT interval ( 29213071 24952745 29874175) Total cholesterol levels ( 30275531) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 34021172)	Frailty index ( 34431594)
Interacting Genes		2 interacting genes: LEO1 RPH3AL	8 interacting genes: BHLHB9 CSNK2A1 CTNNB1 ERCC6 H1-2 POLR2A TCEA1 TCEA3
Entrez ID		6920	123169
HPRD ID		16036	11231
Ensembl ID		ENSG00000204219	ENSG00000166477
Uniprot IDs		B4DUM4 O75764	Q8WVC0
PDB IDs			4M6T 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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