LEO1 and H1-2

Number of citations of the paper that reports this interaction (PubMedID 24360965)
27

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		LEO1	H1-2
Description		LEO1 homolog, Paf1/RNA polymerase II complex component	H1.2 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex	Nucleosome Euchromatin Nucleus Transcriptionally Active Chromatin
	Molecular Function	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Endodermal Cell Fate Commitment Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Frailty index ( 34431594)
Interacting Genes		8 interacting genes: BHLHB9 CSNK2A1 CTNNB1 ERCC6 H1-2 POLR2A TCEA1 TCEA3	29 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 HELLS IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12 YBX1
Entrez ID		123169	3006
HPRD ID		11231	07514
Ensembl ID		ENSG00000166477	ENSG00000187837
Uniprot IDs		Q8WVC0	P16403
PDB IDs		4M6T 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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