LEO1 and TCEA1

Number of citations of the paper that reports this interaction (PubMedID 20178742)
137

Data Source:
BioGRID (pull down, affinity chromatography technology)

		LEO1	TCEA1
Description		LEO1 homolog, Paf1/RNA polymerase II complex component	transcription elongation factor A1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex	Nucleus Nucleoplasm Transcription Factor TFIID Complex Nucleolus
	Molecular Function	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Endodermal Cell Fate Commitment Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation	Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Exoribonuclease Activity
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Frailty index ( 34431594)	Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		8 interacting genes: BHLHB9 CSNK2A1 CTNNB1 ERCC6 H1-2 POLR2A TCEA1 TCEA3	18 interacting genes: APP CDC73 CDK7 CIR1 CTDP1 CTR9 EAF2 GPKOW GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 UBR5 WDR61
Entrez ID		123169	6917
HPRD ID		11231	03252
Ensembl ID		ENSG00000166477	ENSG00000187735
Uniprot IDs		Q8WVC0	A0A384MTX4 B7Z4W0 P23193
PDB IDs		4M6T 6GMH 6TED	1TFI 3NDQ 5IY6 5IY7 5IY8 5IYA 5IYB 5IYC 6O9L
Enriched GO Terms of Interacting Partners?
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