LEO1 and TCEA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LEO1	TCEA3
Description		LEO1 homolog, Paf1/RNA polymerase II complex component	transcription elongation factor A3
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex	Nucleus
	Molecular Function	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Endodermal Cell Fate Commitment Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Frailty index ( 34431594)	Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Creatinine levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) HDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) QT interval ( 29213071 24952745 29874175) Total cholesterol levels ( 30275531) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: BHLHB9 CSNK2A1 CTNNB1 ERCC6 H1-2 POLR2A TCEA1 TCEA3	2 interacting genes: LEO1 RPH3AL
Entrez ID		123169	6920
HPRD ID		11231	16036
Ensembl ID		ENSG00000166477	ENSG00000204219
Uniprot IDs		Q8WVC0	B4DUM4 O75764
PDB IDs		4M6T 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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