LEO1 and BHLHB9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LEO1	BHLHB9
Description		LEO1 homolog, Paf1/RNA polymerase II complex component	basic helix-loop-helix family member b9
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex	Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Endodermal Cell Fate Commitment Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation	Learning Or Memory Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Frailty index ( 34431594)
Interacting Genes		8 interacting genes: BHLHB9 CSNK2A1 CTNNB1 ERCC6 H1-2 POLR2A TCEA1 TCEA3	59 interacting genes: ANKRD11 APP AQP1 BEX2 C2CD6 CCDC120 CDC23 CDC37 CDCA7L CT55 DDX6 EAF1 EIF3B ENKD1 FAM124B FAM161A FAM214B FAM90A1 GAS8 GEM GPANK1 HOXA1 INO80B IPO5 IQUB KLHL38 L3MBTL2 LEO1 LMO1 LONRF1 MFAP1 MISP MPP1 MYO15B NRIP1 OTX1 PALS1 PHF1 PNMA5 POLR1C PPP2R5E PRKAB2 PRPF31 RCOR3 SCNM1 SH3KBP1 SMARCD1 SPANXN2 TASOR2 TCEA2 TEPSIN THOC1 TLK1 TOP3B TSGA10IP TXN2 USP2 USP20 ZNF417
Entrez ID		123169	80823
HPRD ID		11231	10028
Ensembl ID		ENSG00000166477	ENSG00000198908
Uniprot IDs		Q8WVC0	Q6PI77
PDB IDs		4M6T 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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