TCEA1 and LEO1

Number of citations of the paper that reports this interaction (PubMedID 20178742)
137

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TCEA1	LEO1
Description		transcription elongation factor A1	LEO1 homolog, Paf1/RNA polymerase II complex component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIID Complex Nucleolus	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding
	Biological Process	Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Exoribonuclease Activity	Endodermal Cell Fate Commitment Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Urinary albumin-to-creatinine ratio ( 26631737)	Frailty index ( 34431594)
Interacting Genes		18 interacting genes: APP CDC73 CDK7 CIR1 CTDP1 CTR9 EAF2 GPKOW GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 UBR5 WDR61	8 interacting genes: BHLHB9 CSNK2A1 CTNNB1 ERCC6 H1-2 POLR2A TCEA1 TCEA3
Entrez ID		6917	123169
HPRD ID		03252	11231
Ensembl ID		ENSG00000187735	ENSG00000166477
Uniprot IDs		A0A384MTX4 B7Z4W0 P23193	Q8WVC0
PDB IDs		1TFI 3NDQ 5IY6 5IY7 5IY8 5IYA 5IYB 5IYC 6O9L	4M6T 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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