NCF1 and SRSF2

Number of citations of the paper that reports this interaction (PubMedID 16052631)
35

Data Source:
BioGRID (two hybrid)

		NCF1	SRSF2
Description		neutrophil cytosolic factor 1	serine and arginine rich splicing factor 2
Image
GO Annotations	Cellular Component	Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol PML Body Nuclear Speck Interchromatin Granule
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding	Transcription Corepressor Activity RNA Binding Protein Kinase C Binding Protein Binding Pre-mRNA Binding
	Biological Process	Protein Targeting To Membrane Superoxide Metabolic Process Apoptotic Process Cellular Defense Response Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Electron Transport Chain Cellular Response To Reactive Oxygen Species Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Cadmium Ion Positive Regulation Of P38MAPK Cascade Reactive Oxygen Species Biosynthetic Process	Mitotic Cell Cycle Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Vitamin E Negative Regulation Of Transcription, DNA-templated
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Dextromethorphan
Diseases
GWAS		Systemic lupus erythematosus ( 33493351)
Interacting Genes		28 interacting genes: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9	34 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRPK2 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2
Entrez ID		653361	6427
HPRD ID			02888
Ensembl ID		ENSG00000158517	ENSG00000161547
Uniprot IDs		P14598	A0A024R8U5 Q01130 Q53FN0
PDB IDs		1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP	2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?
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