NCF1 and GAA

Number of citations of the paper that reports this interaction (PubMedID 16052631)
35

Data Source:
BioGRID (two hybrid)

		NCF1	GAA
Description		neutrophil cytosolic factor 1	alpha glucosidase
Image
GO Annotations	Cellular Component	Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body	Lysosome Lysosomal Membrane Plasma Membrane Membrane Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Carbohydrate Binding Maltose Alpha-glucosidase Activity Alpha-glucosidase Activity
	Biological Process	Protein Targeting To Membrane Superoxide Metabolic Process Apoptotic Process Cellular Defense Response Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Electron Transport Chain Cellular Response To Reactive Oxygen Species Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Cadmium Ion Positive Regulation Of P38MAPK Cascade Reactive Oxygen Species Biosynthetic Process	Maltose Metabolic Process Regulation Of The Force Of Heart Contraction Diaphragm Contraction Heart Morphogenesis Glycogen Catabolic Process Sucrose Metabolic Process Glucose Metabolic Process Lysosome Organization Locomotory Behavior Tissue Development Vacuolar Sequestering Muscle Cell Cellular Homeostasis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Cardiac Muscle Contraction
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	Glycogen storage disease type II (GAA) Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Dextromethorphan	Acarbose Miglitol AT2220
Diseases
GWAS		Systemic lupus erythematosus ( 33493351)	Blood protein levels ( 30072576) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		28 interacting genes: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9	10 interacting genes: CPEB2 CREBBP DYNC1LI2 EP300 HIVEP1 NCF1 NUMBL PARD3B SH3GLB2 STAT2
Entrez ID		653361	2548
HPRD ID			06006
Ensembl ID		ENSG00000158517	ENSG00000171298
Uniprot IDs		P14598	P10253
PDB IDs		1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP	5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8
Enriched GO Terms of Interacting Partners?
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