SRSF2 and CDK12

Number of citations of the paper that reports this interaction (PubMedID 11683387)
51

Data Source:
HPRD (in vivo, in vitro)

		SRSF2	CDK12
Description		serine and arginine rich splicing factor 2	cyclin dependent kinase 12
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol PML Body Nuclear Speck Interchromatin Granule	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Kinase C Binding Protein Binding Pre-mRNA Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Vitamin E Negative Regulation Of Transcription, DNA-templated	Transcription Elongation From RNA Polymerase II Promoter MRNA Processing Protein Phosphorylation RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MAP Kinase Activity Regulation Of RNA Splicing Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS			Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Refractive error ( 32231278) Triglyceride levels ( 30108155)
Interacting Genes		34 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRPK2 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2	19 interacting genes: AP1M2 CDKN1A CLK1 DDB1 EWSR1 FNDC8 GSDMB MBP PCDHB14 PCNT PDLIM7 PIN1 POLR2A PRPF40A RPL13 SLFN12 SRPK2 SRSF1 SRSF2
Entrez ID		6427	51755
HPRD ID		02888	10849
Ensembl ID		ENSG00000161547	ENSG00000167258
Uniprot IDs		A0A024R8U5 Q01130 Q53FN0	Q9NYV4
PDB IDs		2KN4 2LEA 2LEB 2LEC	4CXA 4NST 4UN0 5ACB 6B3E 6CKX 6TD3
Enriched GO Terms of Interacting Partners?
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