NCF1 and MGAM

Number of citations of the paper that reports this interaction (PubMedID 16052631)
35

Data Source:
BioGRID (two hybrid)

		NCF1	MGAM
Description		neutrophil cytosolic factor 1	maltase-glucoamylase
Image
GO Annotations	Cellular Component	Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding	Catalytic Activity Glucan 1,4-alpha-glucosidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Protein Binding Carbohydrate Binding Maltose Alpha-glucosidase Activity
	Biological Process	Protein Targeting To Membrane Superoxide Metabolic Process Apoptotic Process Cellular Defense Response Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Electron Transport Chain Cellular Response To Reactive Oxygen Species Superoxide Anion Generation Innate Immune Response Respiratory Burst Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Cadmium Ion Positive Regulation Of P38MAPK Cascade Reactive Oxygen Species Biosynthetic Process	Maltose Metabolic Process Starch Catabolic Process
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	Digestion of dietary carbohydrate Neutrophil degranulation
Drugs		Dextromethorphan	Acarbose Miglitol Voglibose
Diseases
GWAS		Systemic lupus erythematosus ( 33493351)	1,5-anhydroglucitol levels ( 28588231) Anorexia nervosa ( 23568457) Blood metabolite levels ( 24816252) Idiopathic dilated cardiomyopathy ( 29495422)
Interacting Genes		28 interacting genes: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9	8 interacting genes: AQP6 ARF6 CPLX4 CREB3L1 GPR42 NCF1 SLC18A1 TMEM14B
Entrez ID		653361	8972
HPRD ID			01104
Ensembl ID		ENSG00000158517	ENSG00000257335
Uniprot IDs		P14598	E7ER45 O43451
PDB IDs		1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP	2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP
Enriched GO Terms of Interacting Partners?
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