CDK12 and RPL13

		CDK12	RPL13
Description		cyclin dependent kinase 12	ribosomal protein L13
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex	Nucleus Nucleolus Endoplasmic Reticulum Cytosol Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding Protein Serine Kinase Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Transcription Elongation From RNA Polymerase II Promoter MRNA Processing Protein Phosphorylation RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MAP Kinase Activity Regulation Of RNA Splicing Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation	Blastocyst Development Cytoplasmic Translation Translation Bone Development
Pathways		TP53 Regulates Transcription of DNA Repair Genes	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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Diseases
GWAS		Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Refractive error ( 32231278) Triglyceride levels ( 30108155)	Hair morphology traits ( 30166351)
Interacting Genes		19 interacting genes: AP1M2 CDKN1A CLK1 DDB1 EWSR1 FNDC8 GSDMB MBP PCDHB14 PCNT PDLIM7 PIN1 POLR2A PRPF40A RPL13 SLFN12 SRPK2 SRSF1 SRSF2	23 interacting genes: ANXA7 CDK12 CEP70 CSNK2A1 CSNK2B DAXX DUX4 ERCC6 HSBP1 ILK IPO5 MAP2K3 MAPKAPK5 OGT PTEN RAD21 RELA SMN1 SPP1 SRPK2 TERF2 TK1 UPF2
Entrez ID		51755	6137
HPRD ID		10849	06428
Ensembl ID		ENSG00000167258	ENSG00000167526
Uniprot IDs		Q9NYV4	A8K4C8 P26373
PDB IDs		4CXA 4NST 4UN0 5ACB 6B3E 6CKX 6TD3	4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP
Enriched GO Terms of Interacting Partners?
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