CDK12 and PDLIM7

		CDK12	PDLIM7
Description		cyclin dependent kinase 12	PDZ and LIM domain 7
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding Protein Serine Kinase Activity	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Transcription Elongation From RNA Polymerase II Promoter MRNA Processing Protein Phosphorylation RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MAP Kinase Activity Regulation Of RNA Splicing Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation	Ossification Receptor-mediated Endocytosis Heart Development Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Osteoblast Differentiation Muscle Structure Development
Pathways		TP53 Regulates Transcription of DNA Repair Genes	RET signaling
Drugs
Diseases
GWAS		Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Refractive error ( 32231278) Triglyceride levels ( 30108155)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: AP1M2 CDKN1A CLK1 DDB1 EWSR1 FNDC8 GSDMB MBP PCDHB14 PCNT PDLIM7 PIN1 POLR2A PRPF40A RPL13 SLFN12 SRPK2 SRSF1 SRSF2	63 interacting genes: ABI2 AP5B1 BAG3 BSG CATSPER1 CCDC185 CDK12 DDX6 DGCR6 DNER ENKD1 FAM214B FAM71C FAM90A1 FNDC11 FRS3 GEM GFAP GPATCH2L HEY2 HNRNPD HNRNPF HSF2BP HSPB7 IL16 IQGAP1 KANK2 MDM2 NUDT10 OTUD6A PAK5 PARVG PCBP1 PHF1 PIN1 PLEKHN1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RASGEF1B RET RPP25 SCNM1 SH2B2 SH3BP2 SLAIN1 SMURF1 SPP1 TCF19 TNPO2 TP53 TPM2 TRAF2 TRAF3 TSG101 TSGA10IP UBE2I UBQLN4 WWP2 ZMYND11 ZNF165
Entrez ID		51755	9260
HPRD ID		10849	10436
Ensembl ID		ENSG00000167258	ENSG00000196923
Uniprot IDs		Q9NYV4	Q9NR12
PDB IDs		4CXA 4NST 4UN0 5ACB 6B3E 6CKX 6TD3	2Q3G
Enriched GO Terms of Interacting Partners?
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