CDK12 and SRSF2

Number of citations of the paper that reports this interaction (PubMedID 11683387)
51

Data Source:
HPRD (in vivo, in vitro)

		CDK12	SRSF2
Description		cyclin dependent kinase 12	serine and arginine rich splicing factor 2
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol PML Body Nuclear Speck Interchromatin Granule
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding Protein Serine Kinase Activity	Transcription Corepressor Activity RNA Binding Protein Kinase C Binding Protein Binding Pre-mRNA Binding
	Biological Process	Transcription Elongation From RNA Polymerase II Promoter MRNA Processing Protein Phosphorylation RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MAP Kinase Activity Regulation Of RNA Splicing Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation	Mitotic Cell Cycle Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Vitamin E Negative Regulation Of Transcription, DNA-templated
Pathways		TP53 Regulates Transcription of DNA Repair Genes	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Refractive error ( 32231278) Triglyceride levels ( 30108155)
Interacting Genes		19 interacting genes: AP1M2 CDKN1A CLK1 DDB1 EWSR1 FNDC8 GSDMB MBP PCDHB14 PCNT PDLIM7 PIN1 POLR2A PRPF40A RPL13 SLFN12 SRPK2 SRSF1 SRSF2	34 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRPK2 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2
Entrez ID		51755	6427
HPRD ID		10849	02888
Ensembl ID		ENSG00000167258	ENSG00000161547
Uniprot IDs		Q9NYV4	A0A024R8U5 Q01130 Q53FN0
PDB IDs		4CXA 4NST 4UN0 5ACB 6B3E 6CKX 6TD3	2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?
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