RAB27A and RABGGTB

Number of citations of the paper that reports this interaction (PubMedID 12802062)
64

Data Source:
HPRD (in vitro)

		RAB27A	RABGGTB
Description		RAB27A, member RAS oncogene family	Rab geranylgeranyltransferase subunit beta
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Lysosome Late Endosome Golgi Apparatus Cytosol Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Small GTPase Binding
	Biological Process	Protein Targeting Exocytosis Blood Coagulation Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion	Cellular Protein Modification Process Visual Perception Protein Prenylation Protein Geranylgeranylation
Pathways		Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation
Drugs			N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS		Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)	Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)
Interacting Genes		29 interacting genes: ADRB2 APP BACE2 CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16	21 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A RABGGTA RPS6KA1 SH3GLB1 TAFA1 TMEM25 WDR4
Entrez ID		5873	5876
HPRD ID		04845	01532
Ensembl ID		ENSG00000069974	ENSG00000137955
Uniprot IDs		A2RU94 P51159	A8KAJ2 P53611 Q6IB63
PDB IDs		6HUF	6J6X 6J74 6J7F 6J7X 6O60
Enriched GO Terms of Interacting Partners?
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