KLHL35 and ALAS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		KLHL35	ALAS1
Description		kelch like family member 35	5'-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Protein Binding	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process		Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Hemoglobin Biosynthetic Process Erythrocyte Development
Pathways			Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs			Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		13 interacting genes: ACVR1 ALAS1 APPBP2 CALCOCO2 DNAJB13 FAM25A FAM25C FAM25G GOLGA6L9 MX1 NCK2 TGFBR1 UBTD2	55 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		283212	211
HPRD ID		08747	00505
Ensembl ID		ENSG00000149243	ENSG00000023330
Uniprot IDs		Q6PF15	B4DVA0 P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?
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