ALAS1 and FBXL8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALAS1	FBXL8
Description		5'-aminolevulinate synthase 1	F-box and leucine rich repeat protein 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nucleus Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Hemoglobin Biosynthetic Process Erythrocyte Development	G2/M Transition Of Mitotic Cell Cycle SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Cycle
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		55 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	4 interacting genes: ALAS1 ORC4 PICK1 SKP1
Entrez ID		211	55336
HPRD ID		00505	16430
Ensembl ID		ENSG00000023330	ENSG00000135722
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q96CD0
PDB IDs
Enriched GO Terms of Interacting Partners?
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