ALAS1 and EP400

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		ALAS1	EP400
Description		5'-aminolevulinate synthase 1	E1A binding protein p400
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Swr1 Complex Nucleoplasm Nuclear Speck NuA4 Histone Acetyltransferase Complex
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP-dependent Chromatin Remodeler Activity Protein Antigen Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Hemoglobin Biosynthetic Process Erythrocyte Development	Histone H4 Acetylation Histone H2A Acetylation
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis	Formation of Senescence-Associated Heterochromatin Foci (SAHF) DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Body mass index ( 26426971) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		55 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	13 interacting genes: ALAS1 BRD8 KAT5 MNS1 MYC NTAQ1 POLR1C RAD51 SUMO2 TBC1D4 TRAF2 TRRAP ZGPAT
Entrez ID		211	57634
HPRD ID		00505	09378
Ensembl ID		ENSG00000023330	ENSG00000183495
Uniprot IDs		B4DVA0 P13196 Q5JAM2	Q96L91
PDB IDs
Enriched GO Terms of Interacting Partners?
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