ALAS1 and GRXCR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALAS1	GRXCR1
Description		5'-aminolevulinate synthase 1	glutaredoxin and cysteine rich domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Microvillus Stereocilium Kinocilium
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	Molecular_function Protein Binding Glutathione Oxidoreductase Activity
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Hemoglobin Biosynthetic Process Erythrocyte Development	Sensory Perception Of Sound Vestibular Receptor Cell Development Inner Ear Receptor Cell Development Inner Ear Receptor Cell Stereocilium Organization
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Interferon alpha levels in systemic lupus erythematosus ( 25338677) Obesity-related traits ( 23251661) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Takayasu arteritis ( 25604533) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		55 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	11 interacting genes: ALAS1 BAIAP2L2 BEND4 CAP2 DCAF4L1 INCA1 PICK1 PRDM6 SDCBP SNX32 TEX11
Entrez ID		211	389207
HPRD ID		00505	19018
Ensembl ID		ENSG00000023330	ENSG00000215203
Uniprot IDs		B4DVA0 P13196 Q5JAM2	A8MXD5
PDB IDs
Enriched GO Terms of Interacting Partners?
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