ALAS1 and GNL3L

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ALAS1	GNL3L
Description		5'-aminolevulinate synthase 1	G protein nucleolar 3 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytosol Membrane
	Molecular Function	5-aminolevulinate Synthase Activity Protein Binding Pyridoxal Phosphate Binding Identical Protein Binding	RNA Binding Protein Binding GTP Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Hemoglobin Biosynthetic Process Erythrocyte Development	Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Protein Binding Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Sumoylation Ribosome Biogenesis Positive Regulation Of Protein Localization To Chromosome, Telomeric Region
Pathways		Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis
Drugs		Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Prostate cancer ( 31562322)
Interacting Genes		55 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL DUSP19 EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564	13 interacting genes: ADRB2 ALAS1 DYNLL1 GOLGA2 HMBOX1 HSF2BP LDOC1 LZTS2 MTUS2 PRKAR1B ROPN1 TERF1 TRIM54
Entrez ID		211	54552
HPRD ID		00505	06514
Ensembl ID		ENSG00000023330	ENSG00000130119
Uniprot IDs		B4DVA0 P13196 Q5JAM2	A0A024R9Y6 Q05DU1 Q9NVN8
PDB IDs
Enriched GO Terms of Interacting Partners?
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