ALOX5AP and LTC4S

Number of citations of the paper that reports this interaction (PubMedID 19233132)
5

Data Source:
BioGRID (pull down)

		ALOX5AP	LTC4S
Description		arachidonate 5-lipoxygenase activating protein	leukotriene C4 synthase
Image
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Nuclear Membrane	Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Arachidonate 5-lipoxygenase Activity Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein-containing Complex Binding Protein N-terminus Binding Arachidonic Acid Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding
	Biological Process	Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Acute Inflammatory Response Leukotriene Biosynthetic Process Lipoxygenase Pathway Regulation Of Catalytic Activity Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification	Leukotriene Metabolic Process Leukotriene Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Cellular Oxidant Detoxification
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX)	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Drugs		DG031 AM103 Fiboflapon	Glutathione Azelastine
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)
Interacting Genes		12 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 FLT1 GDF15 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B	13 interacting genes: ALOX5 ALOX5AP BACE2 CD79A CREB3L1 EBP FFAR3 FXYD3 GPR152 GPR42 MGST1 SLC7A14 TMEM52B
Entrez ID		241	4056
HPRD ID		04742	02004
Ensembl ID		ENSG00000132965	ENSG00000213316
Uniprot IDs		A0A087WW23 P20292	Q16873
PDB IDs		2Q7M 2Q7R 6VGC 6VGI	2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D
Enriched GO Terms of Interacting Partners?
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