ALOX5AP and FLT1

		ALOX5AP	FLT1
Description		arachidonate 5-lipoxygenase activating protein	fms related receptor tyrosine kinase 1
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GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Nuclear Membrane	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Receptor Complex
	Molecular Function	Arachidonate 5-lipoxygenase Activity Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein-containing Complex Binding Protein N-terminus Binding Arachidonic Acid Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Placental Growth Factor-activated Receptor Activity
	Biological Process	Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Acute Inflammatory Response Leukotriene Biosynthetic Process Lipoxygenase Pathway Regulation Of Catalytic Activity Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification	Angiogenesis Hematopoietic Progenitor Cell Differentiation Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis Negative Regulation Of Vascular Endothelial Cell Proliferation Hyaloid Vascular Plexus Regression
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX)	Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization
Drugs		DG031 AM103 Fiboflapon	Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Fostamatinib Selpercatinib
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)	Acute respiratory distress syndrome in sepsis ( 31982041) Birth weight ( 31043758) Body mass index ( 26426971) Cognitive performance ( 19734545) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 23364394) Myocardial infarction ( 33532862) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 FLT1 GDF15 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B	33 interacting genes: ALOX5AP ARL2BP ATR CDK8 CRK CTNNB1 FLT3 FYN GRB2 HMGB1 KDR LATS2 MIPEP NCK1 NEDD4 NRP1 NRP2 PGF PIK3R1 PLCG1 PLCG2 PTK2 PTK2B PTPN11 RASSF9 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1
Entrez ID		241	2321
HPRD ID		04742	01297
Ensembl ID		ENSG00000132965	ENSG00000102755
Uniprot IDs		A0A087WW23 P20292	L7RSL3 P17948
PDB IDs		2Q7M 2Q7R 6VGC 6VGI	1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89
Enriched GO Terms of Interacting Partners?
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