ALOX5AP and SLC29A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALOX5AP	SLC29A2
Description		arachidonate 5-lipoxygenase activating protein	solute carrier family 29 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Nuclear Membrane	Nucleolus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Nuclear Membrane Presynapse
	Molecular Function	Arachidonate 5-lipoxygenase Activity Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein-containing Complex Binding Protein N-terminus Binding Arachidonic Acid Binding	Neurotransmitter Transmembrane Transporter Activity Nucleoside Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity
	Biological Process	Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Acute Inflammatory Response Leukotriene Biosynthetic Process Lipoxygenase Pathway Regulation Of Catalytic Activity Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification	Neurotransmitter Uptake Neurotransmitter Transport Adenine Transport Guanine Transport Nucleoside Transport Purine Nucleoside Transmembrane Transport Uridine Transport Adenosine Transport Hypoxanthine Transport Thymine Transport Pyrimidine-containing Compound Transmembrane Transport Neurotransmitter Reuptake Transport Across Blood-brain Barrier Nucleoside Transmembrane Transport
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX)	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Drugs		DG031 AM103 Fiboflapon	Ethanol
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)	Bipolar disorder ( 21926972) Serum metabolite levels ( 33031748) Serum uric acid levels ( 32514006)
Interacting Genes		12 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 FLT1 GDF15 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B	19 interacting genes: ALOX5AP CERS3 CERS4 CREB3 ERGIC3 GJA4 GPR152 LAPTM4B PLPP5 SERINC2 SLC10A1 SLC10A6 TMEM237 TMEM242 TMEM33 TMEM86B TMX2 UBQLN1 UBQLN2
Entrez ID		241	3177
HPRD ID		04742	03662
Ensembl ID		ENSG00000132965	ENSG00000174669
Uniprot IDs		A0A087WW23 P20292	G5E943 Q14542 Q96FB2
PDB IDs		2Q7M 2Q7R 6VGC 6VGI
Enriched GO Terms of Interacting Partners?
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