ALOX5AP and NAPB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALOX5AP	NAPB
Description		arachidonate 5-lipoxygenase activating protein	NSF attachment protein beta
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Nuclear Membrane	Vacuolar Membrane SNARE Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Arachidonate 5-lipoxygenase Activity Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein-containing Complex Binding Protein N-terminus Binding Arachidonic Acid Binding	Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding
	Biological Process	Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Acute Inflammatory Response Leukotriene Biosynthetic Process Lipoxygenase Pathway Regulation Of Catalytic Activity Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification	Intracellular Protein Transport Regulation Of Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic SNARE Complex Disassembly
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX)	COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs		DG031 AM103 Fiboflapon
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)	Factor VII activity ( 30642921)
Interacting Genes		12 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 FLT1 GDF15 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B	31 interacting genes: ALOX5AP ARL6IP1 BET1 CISD2 CLEC10A CREB3L1 DGAT2L6 FAM209A GJB5 HSD17B13 KCNN3 LEUTX PLEKHO1 SDCBP SIGLEC5 SNAP23 SNAP29 STX16 STX19 STX1A STX1B STX2 STX3 STX4 STX5 STX6 SYT1 SYT2 TAF1B TFEC TMEM139
Entrez ID		241	63908
HPRD ID		04742	17627
Ensembl ID		ENSG00000132965	ENSG00000125814
Uniprot IDs		A0A087WW23 P20292	A0A087WZQ7 Q9H115
PDB IDs		2Q7M 2Q7R 6VGC 6VGI
Enriched GO Terms of Interacting Partners?
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