ALOX5AP and TMEM120B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALOX5AP	TMEM120B
Description		arachidonate 5-lipoxygenase activating protein	transmembrane protein 120B
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Nuclear Membrane	Cellular_component Nuclear Inner Membrane Membrane Integral Component Of Membrane
	Molecular Function	Arachidonate 5-lipoxygenase Activity Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein-containing Complex Binding Protein N-terminus Binding Arachidonic Acid Binding	Molecular_function Ion Channel Activity Protein Binding
	Biological Process	Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Acute Inflammatory Response Leukotriene Biosynthetic Process Lipoxygenase Pathway Regulation Of Catalytic Activity Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification	Biological_process Fat Cell Differentiation Protein Heterooligomerization
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX)
Drugs		DG031 AM103 Fiboflapon
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)	Blood protein levels ( 29875488) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 24026423 32888494 27863252) Mean reticulocyte volume ( 32888494) Molybdenum levels ( 26025379) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 FLT1 GDF15 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B	58 interacting genes: ALOX5AP ANKS6 APOA5 AQP6 AQP8 BNIP3L CCNDBP1 CD74 COMT CPLX4 CREB3L1 DNAH10 EBP ERGIC3 FCER1G FFAR2 FKBP7 GAD2 GJB1 GORAB GPR152 GPRC5D GPX8 HSD17B11 IFNGR2 IL7R JAGN1 JPH1 KCNJ6 LMNA LRRTM2 MGST3 MRPS18B MTRFR MUC1 NCAPH2 REEP2 REEP4 RETREG3 RNF19B RNF5 SCN3B SH3GL3 SLC10A1 SLC10A6 SLC17A8 SLC18A1 SLC1A3 STOM STX2 TLCD4 TMEM139 TMEM143 TMEM14B TMEM80 TMPRSS2 TMX2 ZDHHC15
Entrez ID		241	144404
HPRD ID		04742	19119
Ensembl ID		ENSG00000132965	ENSG00000188735
Uniprot IDs		A0A087WW23 P20292	A0PK00
PDB IDs		2Q7M 2Q7R 6VGC 6VGI
Enriched GO Terms of Interacting Partners?
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