LTC4S and FXYD3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LTC4S	FXYD3
Description		leukotriene C4 synthase	FXYD domain containing ion transport regulator 3
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding	Chloride Channel Activity Sodium Channel Regulator Activity
	Biological Process	Leukotriene Metabolic Process Leukotriene Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Cellular Oxidant Detoxification	Potassium Ion Transport Sodium Ion Transport Chloride Transport Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		Glutathione Azelastine
Diseases
GWAS
Interacting Genes		13 interacting genes: ALOX5 ALOX5AP BACE2 CD79A CREB3L1 EBP FFAR3 FXYD3 GPR152 GPR42 MGST1 SLC7A14 TMEM52B	64 interacting genes: AGR3 ANK1 AQP6 AQP9 BCL2L13 BEST2 CD79A CNR2 CREB3 CREB3L1 CYB5R3 EBP ERG28 ERGIC3 FAM209A FBXL12 FCGR2A FFAR2 GHITM GPR152 GPR37L1 GPR42 GPRC5D IBSP KASH5 KCNN4 LMNA LTC4S MAPK6 MFSD11 MFSD5 MGST1 MTIF3 NR4A1 NUDT3 PLPP6 SCN3B SERBP1 SGPL1 SLC10A1 SLC10A6 SLC16A12 SLC18A1 SLC1A1 SLC30A2 SLC35A1 SLC35B1 SLC35C2 SLC39A2 SPNS3 STRIT1 STX3 TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM179B TMEM50B TMEM52B TMEM80 TMEM86A TMEM97 TSPO2 XKR3
Entrez ID		4056	5349
HPRD ID		02004	05410
Ensembl ID		ENSG00000213316	ENSG00000089356
Uniprot IDs		Q16873	Q14802
PDB IDs		2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D
Enriched GO Terms of Interacting Partners?
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