SCRIB and C5AR2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		SCRIB	C5AR2
Description		scribble planar cell polarity protein	complement C5a receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Postsynaptic Density Basolateral Plasma Membrane Lamellipodium Cell Junction Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Cell-cell Contact Zone Postsynaptic Membrane Extracellular Exosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function	Protein Binding Cadherin Binding	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Establishment Of T Cell Polarity Neural Tube Closure Positive Regulation Of Receptor Recycling Cell Population Proliferation Embryo Development Synaptic Vesicle Targeting Cell Migration Cochlear Nucleus Development Polarized Epithelial Cell Differentiation Positive Regulation Of Interferon-gamma Production Establishment Of Apical/basal Cell Polarity Post-anal Tail Morphogenesis Wound Healing Positive Regulation Of Apoptotic Process Receptor Clustering Astrocyte Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Activated T Cell Proliferation Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction Activation Of GTPase Activity Receptor Localization To Synapse Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis
Pathways		Asymmetric localization of PCP proteins CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RND3 GTPase cycle RND2 GTPase cycle	Peptide ligand-binding receptors Regulation of Complement cascade
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)
Interacting Genes		14 interacting genes: ACE2 APC ARHGEF7 C5AR2 EXOSC10 LPP MAPK3 OGT PRKCA STX4 TJP2 TRIP6 TSHR UBE3A	17 interacting genes: ABCA7 ACO2 C3 C4A C4orf3 C5AR1 CALM3 HAGHL HERC2 HERPUD1 PLXDC1 SCN1B SCRIB SLC25A11 SLC26A11 SYNGR2 TMEM234
Entrez ID		23513	27202
HPRD ID		06984	17072
Ensembl ID		ENSG00000180900	ENSG00000134830
Uniprot IDs		A0A0G2JNZ2 A0A0G2JPP5 A0PJK8 Q14160	Q9P296
PDB IDs		1UJU 1WHA 1X5Q 2W4F 4WYT 4WYU 5VWC 5VWI 5VWK 6EEY 6ESP 6MS1 6MTU 6MTV 6MYE 6MYF
Enriched GO Terms of Interacting Partners?
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