RAB3D and CHM

Data Source:
HPRD (in vivo, in vitro)

		RAB3D	CHM
Description		RAB3D, member RAS oncogene family	CHM Rab escort protein
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytoplasmic Microtubule Plasma Membrane Synaptic Vesicle Azurophil Granule Membrane Zymogen Granule Extracellular Exosome Secretory Vesicle	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GTP-dependent Protein Binding Myosin V Binding	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Protein Secretion Regulation Of Exocytosis Peptidyl-cysteine Methylation Neutrophil Degranulation Bone Resorption Protein Localization To Plasma Membrane Positive Regulation Of Regulated Secretory Pathway	Protein Targeting To Membrane Small GTPase Mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Phosphopantetheinylation Protein Geranylgeranylation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Post-translational Protein Modification
Pathways		Neutrophil degranulation RAB geranylgeranylation	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Choroideremia (CHM); Tapetochoroidal dystrophy
GWAS		Early cardiac repolarization ( 31600170) HDL cholesterol ( 23505323)	Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)
Interacting Genes		15 interacting genes: AKT1 AKT2 AP1M2 APP CEP55 CHM CYP2C9 MAST1 RAB3IP RABIF RIMS2 RNF32 RPH3AL SYTL4 VRTN	11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A
Entrez ID		9545	1121
HPRD ID		05070	02312
Ensembl ID		ENSG00000105514	ENSG00000188419
Uniprot IDs		A0A024R7G2 O95716	A8K545 B4DRL9 P24386
PDB IDs		2GF9
Enriched GO Terms of Interacting Partners?
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