RAB3D and RIMS2

Data Source:
HPRD (in vitro)

		RAB3D	RIMS2
Description		RAB3D, member RAS oncogene family	regulating synaptic membrane exocytosis 2
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GO Annotations	Cellular Component	Endosome Cytoplasmic Microtubule Plasma Membrane Synaptic Vesicle Azurophil Granule Membrane Zymogen Granule Extracellular Exosome Secretory Vesicle	Presynaptic Membrane Cell Projection Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GTP-dependent Protein Binding Myosin V Binding	Protein Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Protein Secretion Regulation Of Exocytosis Peptidyl-cysteine Methylation Neutrophil Degranulation Bone Resorption Protein Localization To Plasma Membrane Positive Regulation Of Regulated Secretory Pathway	Intracellular Protein Transport Positive Regulation Of Gene Expression Calcium-ion Regulated Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Cell Differentiation Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Dendrite Extension Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Neutrophil degranulation RAB geranylgeranylation
Drugs
Diseases
GWAS		Early cardiac repolarization ( 31600170) HDL cholesterol ( 23505323)	Cocaine dependence ( 23958962) Dietary fat liking ( 32516399) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High density lipoprotein cholesterol levels ( 30498476) Monoclonal gammopathy of undetermined significance ( 30737484) Multiple system atrophy (pathologically confirmed) ( 27629089)
Interacting Genes		15 interacting genes: AKT1 AKT2 AP1M2 APP CEP55 CHM CYP2C9 MAST1 RAB3IP RABIF RIMS2 RNF32 RPH3AL SYTL4 VRTN	12 interacting genes: ABCA1 CACNA1S RAB27A RAB3A RAB3B RAB3C RAB3D RAB8A RABAC1 RAPGEF4 RPH3AL YWHAH
Entrez ID		9545	9699
HPRD ID		05070	09436
Ensembl ID		ENSG00000105514	ENSG00000176406
Uniprot IDs		A0A024R7G2 O95716	Q9UQ26
PDB IDs		2GF9	1V27 1WFG
Enriched GO Terms of Interacting Partners?
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