NEURL1 and UBE2H

Data Source:
BioGRID (two hybrid)

		NEURL1	UBE2H
Description		neuralized E3 ubiquitin protein ligase 1	ubiquitin conjugating enzyme E2 H
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Dendritic Spine Perikaryon Perinuclear Region Of Cytoplasm Apical Dendrite	Nucleus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Translation Factor Activity, Non-nucleic Acid Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of Translation Protein Monoubiquitination Notch Signaling Pathway Sperm Axoneme Assembly Nervous System Development Brain Development Skeletal Muscle Tissue Development Lactation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Filopodium Assembly Positive Regulation Of Dendritic Spine Development Cellular Response To Amino Acid Stimulus Positive Regulation Of Synapse Maturation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 28416822 30061737) Early onset atrial fibrillation ( 28460022) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29617998) Ischemic stroke (cardioembolic) ( 29531354) Prevalent atrial fibrillation ( 28416818) Response to antidepressants (symptom improvement) ( 29160301)	Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: UBE2D1 UBE2H UBE2N	68 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBA1 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		9148	7328
HPRD ID		04815	03052
Ensembl ID		ENSG00000107954	ENSG00000186591
Uniprot IDs		B4DS86 O76050	A0A3B3IU20 A4D1L5 P62256
PDB IDs			2Z5D
Enriched GO Terms of Interacting Partners?
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