UBE2H and RNF144A

Data Source:
BioGRID (two hybrid)

		UBE2H	RNF144A
Description		ubiquitin conjugating enzyme E2 H	ring finger protein 144A
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GO Annotations	Cellular Component	Nucleus Cytosol	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)	Allergic rhinitis ( 30013184) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)
Interacting Genes		68 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBA1 UBASH3B UBOX5 UBR2 UBR3	27 interacting genes: CYSLTR2 DGAT2L6 E2F1 E2F2 E2F3 E2F4 EGFR MFSD5 PAQR6 PARP1 RFT1 SEC22A SGTA SGTB SLC7A1 TMEM31 UBC UBE2D1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32 YIF1A
Entrez ID		7328	9781
HPRD ID		03052	11510
Ensembl ID		ENSG00000186591	ENSG00000151692
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	P50876
PDB IDs		2Z5D	1WIM
Enriched GO Terms of Interacting Partners?
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