UBE2H and MAEA

Data Source:
BioGRID (enzymatic study)

		UBE2H	MAEA
Description		ubiquitin conjugating enzyme E2 H	macrophage erythroblast attacher, E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Spindle Actomyosin Contractile Ring Cytoskeleton Integral Component Of Plasma Membrane Nuclear Matrix GID Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Actin Binding Ubiquitin-protein Transferase Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Cell Cycle Cell Adhesion Regulation Of Mitotic Cell Cycle Protein Ubiquitination Negative Regulation Of Myeloid Cell Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Negative Regulation Of Gluconeogenesis Cell Division
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Tetrachlorodecaoxide
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)	Obesity-related traits ( 23251661) Pulse pressure ( 30224653) Type 2 diabetes ( 30297969 26818947 23945395 32499647 22158537 30718926 28869590)
Interacting Genes		68 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBA1 UBASH3B UBOX5 UBR2 UBR3	12 interacting genes: ARMC8 GID4 GID8 MKLN1 MYOC RANBP10 RMND5A UBE2D2 UBE2D3 UBE2H UBE2R2 YPEL5
Entrez ID		7328	10296
HPRD ID		03052	08427
Ensembl ID		ENSG00000186591	ENSG00000090316
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	B3KRN7 B4DJP8 B4DQT1 B4DVN3 D6RIB6 Q7L5Y9
PDB IDs		2Z5D
Enriched GO Terms of Interacting Partners?
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