UBE2H and POLM

Data Source:
BioGRID (enzymatic study)

		UBE2H	POLM
Description		ubiquitin conjugating enzyme E2 H	DNA polymerase mu
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GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Biosynthetic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		68 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBA1 UBASH3B UBOX5 UBR2 UBR3	13 interacting genes: CEP55 CTAG1A CTAG1B IKZF3 PCNA PNMA1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H USHBP1
Entrez ID		7328	27434
HPRD ID		03052	16208
Ensembl ID		ENSG00000186591	ENSG00000122678
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	Q9NP87
PDB IDs		2Z5D	2DUN 2HTF 4LZD 4LZG 4M04 4M0A 4YCX 4YD1 4YD2 5TWP 5TWQ 5TWR 5TWS 5TXX 5TXZ 5TYB 5TYC 5TYD 5TYE 5TYF 5TYG 5TYU 5TYV 5TYW 5TYX 5TYY 5TYZ 5VZ7 5VZ8 5VZ9 5VZA 5VZB 5VZC 5VZD 5VZE 5VZF 5VZG 5VZH 5VZI 5W4F 5ZLC 6AEC 6AEH 6AK5 6AK6 6AK8 6AK9 6AKH 6IPD 6IPE 6IPF 6IPG 6IPH 6IPI 6IPJ 6IPK 6IPL 6IPM 6IPN 6P1M 6P1N 6P1O 6P1P 6P1Q 6P1R 6P1S 6P1T 6P1U 6P1V 6P1W 6WIC 6WID 6WIE
Enriched GO Terms of Interacting Partners?
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