UBE2H and UBR2

Data Source:
BioGRID (pull down)

		UBE2H	UBR2
Description		ubiquitin conjugating enzyme E2 H	ubiquitin protein ligase E3 component n-recognin 2
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GO Annotations	Cellular Component	Nucleus Cytosol	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Protein Polyubiquitination Chromatin Silencing Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Negative Regulation Of Transposition Protein Ubiquitination Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)	Lung cancer in never smokers ( 28604730) Obesity-related traits ( 23251661) Serum total protein level ( 29403010)
Interacting Genes		68 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBA1 UBASH3B UBOX5 UBR2 UBR3	9 interacting genes: H2AC20 H2BC8 NTAN1 NTAQ1 PKN1 SUOX UBE2B UBE2D2 UBE2H
Entrez ID		7328	23304
HPRD ID		03052	09853
Ensembl ID		ENSG00000186591	ENSG00000024048
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	B3KXG6 Q8IWV8
PDB IDs		2Z5D	3NY2 3NY3 5TDA 5TDB 5TDD 5UM3
Enriched GO Terms of Interacting Partners?
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