UBE2H and RNF146

Data Source:
BioGRID (two hybrid)

		UBE2H	RNF146
Description		ubiquitin conjugating enzyme E2 H	ring finger protein 146
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GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Poly-ADP-D-ribose Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)	Breast cancer ( 18326623) Diverticular disease ( 30177863) Food addiction ( 27106561) Intracranial volume ( 22504418) Subcortical brain region volumes ( 25607358) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		68 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBA1 UBASH3B UBOX5 UBR2 UBR3	11 interacting genes: KASH5 NDUFAF3 PFN2 TGFBR1 TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6
Entrez ID		7328	81847
HPRD ID		03052	11511
Ensembl ID		ENSG00000186591	ENSG00000118518
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	Q9NTX7
PDB IDs		2Z5D	2D8T 3V3L 6CF6
Enriched GO Terms of Interacting Partners?
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