VIL1 and ACTA1

Data Source:
HPRD (in vitro)

		VIL1	ACTA1
Description		villin 1	actin alpha 1, skeletal muscle
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Plasma Membrane Microvillus Brush Border Actin Cytoskeleton Lamellipodium Filopodium Actin Filament Bundle Filopodium Tip Extracellular Exosome	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Dynactin Complex Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lysophosphatidic Acid Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Intestinal D-glucose Absorption Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Actin Polymerization Or Depolymerization Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Epithelial Cell Migration Actin Filament Polymerization Actin Filament Depolymerization Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Depolymerization Epithelial Cell Differentiation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Microvillus Length Cellular Response To Hepatocyte Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Nucleation Actin Filament Severing Barbed-end Actin Filament Capping Regulation Of Actin Nucleation Actin Filament Capping Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Wound Healing Protein-containing Complex Assembly Cellular Response To Epidermal Growth Factor Stimulus Terminal Web Assembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Lamellipodium Morphogenesis Positive Regulation Of Lamellipodium Morphogenesis	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Positive Regulation Of Gene Expression Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development Cellular Response To Organonitrogen Compound Mesenchyme Migration
Pathways			Striated Muscle Contraction
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Congenital fiber type disproportion (CFTD) Cap myopathy Nemaline myopathy
GWAS		Adult body size ( 32376654) Estimated glomerular filtration rate ( 31152163) Height ( 31562340) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494) Red blood cell count ( 27863252)
Interacting Genes		6 interacting genes: ACTA1 ACTG1 JAK3 PLCG1 SRC TEX11	114 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		7429	58
HPRD ID		01898	00030
Ensembl ID		ENSG00000127831	ENSG00000143632
Uniprot IDs		P09327 Q53F91	P68133
PDB IDs		1UNC 3FG7
Enriched GO Terms of Interacting Partners?
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