ACTA1 and CCT2

Data Source:
BioGRID (pull down)

		ACTA1	CCT2
Description		actin alpha 1, skeletal muscle	chaperonin containing TCP1 subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Dynactin Complex Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Zona Pellucida Receptor Complex Extracellular Region Cytosol Chaperonin-containing T-complex Microtubule Azurophil Granule Lumen Cell Body Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Positive Regulation Of Gene Expression Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development Cellular Response To Organonitrogen Compound Mesenchyme Migration	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Neutrophil Degranulation Protein Stabilization Chaperone Mediated Protein Folding Independent Of Cofactor Chaperone-mediated Protein Complex Assembly Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Striated Muscle Contraction	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Congenital fiber type disproportion (CFTD) Cap myopathy Nemaline myopathy
GWAS			Height ( 18391951) Logical memory (delayed recall) in normal cognition ( 29274321) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		114 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	23 interacting genes: ACTA1 ACTB CCT4 EEF2 ERLIN2 ESR1 FCHSD2 HSP90AB1 HSP90B1 LINC01554 NPSR1 PRPF40A PSMC6 PSMD2 PTEN RPS3 SUMO2 SUMO4 TUBA1B VAV2 VRK2 YWHAG ZNRD2
Entrez ID		58	10576
HPRD ID		00030	06895
Ensembl ID		ENSG00000143632	ENSG00000166226
Uniprot IDs		P68133	P78371 V9HW96
PDB IDs			6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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