ACTA1 and TTN

Data Source:
HPRD (in vitro)

		ACTA1	TTN
Description		actin alpha 1, skeletal muscle	titin
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Dynactin Complex Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Condensed Nuclear Chromosome Extracellular Region Cytosol Z Disc I Band Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Positive Regulation Of Gene Expression Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development Cellular Response To Organonitrogen Compound Mesenchyme Migration	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Positive Regulation Of Gene Expression Protein Kinase A Signaling Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Positive Regulation Of Protein Secretion Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Platelet degranulation Striated Muscle Contraction
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Congenital fiber type disproportion (CFTD) Cap myopathy Nemaline myopathy	Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS			Atrial fibrillation ( 29290336 30061737 29892015) Bone mineral density (hip) ( 30172743) Breast size ( 22747683) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Left ventricular ejection fraction ( 32382064) Left ventricular end-diastolic volume ( 32382064) Left ventricular end-systolic volume ( 32382064) PR interval ( 30046033 32439900) QT interval ( 20031603 29213071 24952745 29874175) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278) Resting heart rate ( 27798624) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		114 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	76 interacting genes: ABLIM1 ABLIM2 ACTA1 ACTN1 ACTN2 ACTN3 ACTN4 AMOT ANK1 ANKRD1 ANKRD2 ANKRD23 ANKRD28 ASH2L ATP5F1D C1QTNF9 CALM1 CAPN3 CCT6A CHD4 CLIP4 CRYAB DNAJB5 DNAJB6 ENO1 ENO3 EXOSC10 FHL1 FHL2 FLNA FN1 FNDC3B GABARAP HSPA1B HSPB2 ITGB1BP2 ITGB5 JPH1 LIMS1 MAPK1 MAST2 MYBPC1 MYBPC2 MYBPC3 MYBPH MYCBP2 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB NEK9 NEO1 OBSCN PARD3 PHGDH POMP PYGM RNF167 RPL12 RYR1 SF1 SGCG SH3GLB1 SQSTM1 SRPK2 TAB2 TCAP TRIM55 TRIM63 TSC22D2 TTC3 UBE2I UGP2 VAV2
Entrez ID		58	7273
HPRD ID		00030	01787
Ensembl ID		ENSG00000143632	ENSG00000155657
Uniprot IDs		P68133	A0A0A0MRA3 A0A0A0MTS7 Q7Z3B7 Q8WZ42
PDB IDs			1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3 4C4K 4JNW 4O00 4QEG 4UOW 5BS0 5JDD 5JDE 5JDJ 5JOE 6DL4 6H4L 6HCI 6I0Y 6SDB
Enriched GO Terms of Interacting Partners?
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