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ACTA1 and DHX9
Data Source:
BioGRID
(biochemical, affinity chromatography technology, pull down)
ACTA1
DHX9
Description
actin alpha 1, skeletal muscle
DExH-box helicase 9
Image
No pdb structure
GO Annotations
Cellular Component
Stress Fiber
Extracellular Space
Cytosol
Striated Muscle Thin Filament
Dynactin Complex
Actin Filament
Actin Cytoskeleton
Sarcomere
Lamellipodium
Filopodium
Cell Body
Extracellular Exosome
Blood Microparticle
Intracellular Anatomical Structure
Nucleus
Nucleoplasm
Perichromatin Fibrils
Nucleolus
Cytoplasm
Centrosome
Cytosol
Polysome
Actin Cytoskeleton
Membrane
RISC Complex
Nuclear Body
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
Polysomal Ribosome
RISC-loading Complex
CRD-mediated MRNA Stability Complex
Nuclear Stress Granule
Ribonucleoprotein Complex
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Myosin Binding
ADP Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Complex Binding
Regulatory Region RNA Binding
RNA Polymerase II Transcription Factor Binding
DNA Binding
DNA Helicase Activity
DNA Replication Origin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
RNA Helicase Activity
Double-stranded RNA Binding
Single-stranded RNA Binding
MRNA Binding
Protein Binding
ATP Binding
ATPase Activity
Nucleoside-triphosphatase Activity
Chromatin DNA Binding
3'-5' DNA/RNA Helicase Activity
3'-5' RNA Helicase Activity
SiRNA Binding
RNA Stem-loop Binding
3'-5' DNA Helicase Activity
Triplex DNA Binding
Metal Ion Binding
Nucleoside-triphosphate Diphosphatase Activity
Importin-alpha Family Protein Binding
RNA Polymerase Binding
RISC Complex Binding
Polysome Binding
Single-stranded 3'-5' DNA Helicase Activity
Sequence-specific MRNA Binding
Promoter-specific Chromatin Binding
Biological Process
Muscle Contraction
Response To Mechanical Stimulus
Response To Extracellular Stimulus
Response To Lithium Ion
Positive Regulation Of Gene Expression
Muscle Filament Sliding
Skeletal Muscle Thin Filament Assembly
Skeletal Muscle Fiber Adaptation
Response To Steroid Hormone
Skeletal Muscle Fiber Development
Cellular Response To Organonitrogen Compound
Mesenchyme Migration
Alternative MRNA Splicing, Via Spliceosome
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
DNA Replication
DNA-templated Transcription, Termination
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
RNA Secondary Structure Unwinding
Targeting Of MRNA For Destruction Involved In RNA Interference
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-18 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Protein-containing Complex Assembly
DNA-templated Viral Transcription
G-quadruplex DNA Unwinding
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Export From Nucleus
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Positive Regulation Of Viral Transcription
Regulation Of MRNA Processing
Regulation Of Defense Response To Virus By Host
Positive Regulation Of Inflammatory Response
MRNA Transport
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Response To Cytokine Stimulus
Pyroptosis
Small RNA Loading Onto RISC
CRD-mediated MRNA Stabilization
Cellular Response To Tumor Necrosis Factor
Cellular Response To Exogenous DsRNA
Protein Localization To Cytoplasmic Stress Granule
Positive Regulation Of Viral Translation
Positive Regulation Of Polysome Binding
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Positive Regulation Of Gene Silencing By MiRNA
Regulation Of Cytoplasmic Translation
Positive Regulation Of Cytoplasmic Translation
Pathways
Striated Muscle Contraction
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
mRNA Splicing - Major Pathway
Drugs
Latrunculin A
Sucrose
Ulapualide A
Kabiramide C
Jaspisamide A
Tmr
1-Methylhistidine
Phosphoaminophosphonic Acid-Adenylate Ester
Aplyronine A
Reidispongiolide A
Reidispongiolide C
Sphinxolide B
Latrunculin B
Diseases
Congenital fiber type disproportion (CFTD)
Cap myopathy
Nemaline myopathy
GWAS
Interacting Genes
114 interacting genes:
ABL1
ABRA
ACTR10
ACTR1B
ADSS2
AFAP1
AIF1
AJUBA
AMOT
ANXA2
BIN1
CCIN
CCT2
CCT4
CCT5
CFL1
CLIC5
CNN1
CORO2B
COTL1
CTNND1
CTTN
CYFIP1
CYTH1
DHX9
DLG1
DMD
DNASE1
DNMBP
DTNA
DUX4L9
EGFR
EPB41
EPB41L2
EPS8
FGD4
FHOD1
FSCN1
GAS2
GAS7
GC
GSN
HCLS1
HDAC4
HIP1R
HSPB2
HTRA2
IQGAP1
ITGA2
ITPKA
KIF23
KLHL20
LASP1
MACF1
MAP1A
MAPT
MIB2
MINPP1
MYL1
MYLK
MYO10
MYO6
MYO7A
MYO9B
NEXN
NR3C2
NRAP
PAK1
PARVA
PCYT1B
PFDN1
PFN1
PHACTR1
PLD1
PPP1R9B
PRKCA
PRKCD
PRKCE
RAC1
RNF167
RPS6KB1
S100A1
S100A4
SCIN
SMTN
SNCA
SORBS1
SPRR1A
SPTA1
SPTAN1
SPTBN2
TAGLN
TJP1
TLN1
TMSB4X
TMSB4Y
TNNI1
TNNI3
TNNI3K
TP53
TPM2
TPM3
TRIM55
TRIM63
TTN
UBC
USP25
USP6NL
UTRN
VASP
VAV1
VCL
VIL1
XIRP1
43 interacting genes:
ACTA1
AKAP8L
APBB1
BRCA1
DDX20
DDX5
DUX4
EIF2AK2
ESR1
GEMIN2
GEMIN4
GTF2B
H2AX
HDLBP
HNRNPC
HNRNPK
IL7R
ILF3
JUN
KHDRBS1
LINC01554
MBD2
NXF1
OGA
PCNA
POLR2A
PRMT1
PRPF40A
PRPF8
PTEN
RBM4
RELA
SMN1
SMN2
SNRPB
SNRPB2
SRPK1
SSRP1
STAU1
TBP
TOP2A
UBE2I
YWHAQ
Entrez ID
58
1660
HPRD ID
00030
04386
Ensembl ID
ENSG00000143632
ENSG00000135829
Uniprot IDs
P68133
B3KU66
Q08211
PDB IDs
3LLM
3VYX
3VYY
Enriched GO Terms of Interacting Partners
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